Skip to content
Sufyan Suleman

IsletCalc

Surrogate indices of pancreatic islet hormone release from fasting and OGTT measurements

DocumentationSource on GitHub
R PACKAGEIsletCalcSurrogate indices of pancreaticislet hormone releaseFor Researchers analysingfasting and OGTT measurementssufyansuleman.github.io

Overview

IsletCalc is an R package for computing islet-cell function indices, beta-cell insulin release, alpha-cell glucagon release, and glucagon resistance, from OGTT glucose, insulin and glucagon measurements. Every index follows a published, peer-reviewed formula, with the exact equation, unit conventions and source documented.

Research problem

Beta-cell and alpha-cell function indices depend on combinations of fasting and post-load glucose, insulin and glucagon values, each defined in a separate publication with its own units and assumptions. IsletCalc implements these formulas directly from source so results are traceable to the original equation.

What it computes

  • insulin_release(), beta-cell indices: HOMA-beta, CIR, Stumvoll, insulinogenic (Xinsdg30, Xinsg30), BIGTT-AIR, disposition indices (Di, Dibig)
  • glucagon_release(), alpha-cell indices: fasting glucagon, glucagon AUC
  • glucagon_resistance(), alpha-cell resistance indices: glucagon suppression ratio, fasting glucagon:insulin ratio

Inputs are glucose (G0, G30, G120 in mmol/L), insulin (I0, I30, I120 in pmol/L), sex, BMI, and glucagon (Glucagon0, Glucagon30, Glucagon120 in pmol/L) as available, only the columns needed for the requested indices must be present.

Install

install.packages("IsletCalc")

# development version
remotes::install_github("sufyansuleman/IsletCalc")

Documentation

Full reference and vignettes: https://sufyansuleman.github.io/IsletCalc/



Which beta-cell or glucagon indices do you need, or all of them?

I can help you match the indices to your OGTT and glucagon data and run them across your cohort.

Get in touch