Platform trial data monitoring

Synthetic Adaptive Platform Trial in Critical Illness. Generated 28 August 2026 from rule set 455d0fba76e0.

These are the output of a data management pipeline for a multi-site, multi-country, multi-domain adaptive platform trial: 25 sites across 5 countries, 3 clinical domains running over a shared participant population. The pipeline takes nightly EDC exports in five local formats, conforms them, validates them against a rule set held as configuration rather than code, derives the primary endpoint, and freezes verifiable data cuts. It scores its own validation rules against deliberately injected defects, so the detection rates below are measured rather than asserted.

Central monitoring report. The coordinating centre view: which sites need attention, how well the validation rules actually perform against known defects, and what the ingest layer had to undo. Start here.

Site reports

One per site. Each opens with the actions for that site this week; the charts are the evidence behind them.